Voltammetric Determination of LSD with a Schiff Base – Chemically Modified Electrode in Aqueous Solution

Authors

  • Maria Fernanda M. Ribeiro Universidade de São Paulo – USP- Avenida Bandeirantes, 3900 – Ribeirão Preto – SP – Brazil
  • Erica N. Oiye Universidade de São Paulo – USP- Avenida Bandeirantes, 3900 – Ribeirão Preto – SP – Brazil
  • Juliana M. T. Katayama Universidade de São Paulo – USP- Avenida Bandeirantes, 3900 – Ribeirão Preto – SP – Brazil
  • José W. C. Junior Universidade Federal de Santa Catarina - Rua Pomerode, 710 – Blumenau – SC – Brazil
  • Edward R. Dockal Universidade Federal de São Carlos - Rod. Washington Luis, km 235 - São Carlos - SP – Brazil
  • Marcelo Firmino de Oliveira Faculdade de Filosofia Ciências e Letras de Ribeirão Preto - USP - Ribeirão Preto

DOI:

https://doi.org/10.17063/bjfs9(4)y2020440-458

Keywords:

forensic electroanalysis, LSD, Schiff bases, carbon paste, chemically modified electrodes

Abstract

In recent years, practical, inexpensive, and highly specific electroanalytical methods based on modified electrodes have been increasingly developed for forensic science. Simple modification of the carbon paste electrode with Schiff base complexes has become a promising strategy to detect and quantify narcotics. In this context, we aimed to develop voltammetric methods to quantify lysergic acid diethylamide (LSD) by using a carbon paste electrode modified with the complex [UO2(Ac-ophen)]·H2O. The use of an aqueous solution of KCl as supporting electrolyte makes the methodology less polluting, which contrasts with methods that still employ toxic solvents. The developed method for Differential Pulse Voltammetry provides a linear response at various concentrations of LSD and affords analytical curves with standard deviation, detection, and quantification limits around 2.45, 0.625, and 2.08 μmol L-1, respectively. The recovery values of 103 and 108% prove that the developed method is suitable for application in forensic science.

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Published

2020-09-11

How to Cite

M. Ribeiro, M. F., N. Oiye, E., M. T. Katayama, J., W. C. Junior, J. ., R. Dockal, E., & Firmino de Oliveira, M. (2020). Voltammetric Determination of LSD with a Schiff Base – Chemically Modified Electrode in Aqueous Solution. Brazilian Journal of Forensic Sciences, Medical Law and Bioethics, 9(4), 440–458. https://doi.org/10.17063/bjfs9(4)y2020440-458

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